HRID2187098

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NCc1ccc(C(=O)Oc2ccc(S(=O)(=O)CCN3CC[C@H](Cc4ccccc4)[C@H](O)C3)cc2)cc1

HCID86584796

未命名化合物

PRODUCTS

生成物

结构：NCc1ccc(C(=O)Oc2ccc(S(=O)(=O)CCN3CC[C@H](Cc4ccccc4)[C@H](O)C3)cc2)cc1

HCID10185799

未命名化合物

收率 67%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

A solution of 200 mg 4-(tert-butoxycarbonylamino-methyl)-benzoic acid (3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenyl ester in 3.8 ml TFA was stirred for 1 hour at 0° C. The solvent was removed under reduced pressure and the crude product was diluted in diethylether and 3 drops of a saturated HCl-solution in diethylether were added. Filtration yielded 120 mg (0.22 mmol, 67%) 4-aminomethyl-benzoic acid (3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenyl ester; hydrochloride(1:2) as colorless crystalls.

WORKUP

后处理

customThe solvent was removed under reduced pressure
additionthe crude product was diluted in diethylether
addition3 drops of a saturated HCl-solution in diethylether were added
filtrationFiltration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c27188a72774d6bb990d0582f424a74
来源数据集: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06407235B1
来源说明: uspto-grants-2002_06

反应 SMILES

[CH2:1]([C@H:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26](=[O:42])[C:27]3[CH:32]=[CH:31][C:30]([CH2:33][NH:34]C(OC(C)(C)C)=O)=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][C@H:9]1[OH:43])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[CH2:1]([C@H:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26](=[O:42])[C:27]3[CH:28]=[CH:29][C:30]([CH2:33][NH2:34])=[CH:31][CH:32]=3)=[CH:21][CH:20]=2)(=[O:17])=[O:18])[CH2:10][C@H:9]1[OH:43])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1