Methane → HCID 12968235, compound

HRID 2187107Notes

Reaction equation

HRID 2187107 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:32]=[C:31]([OH:33])[CH:30]=[CH:29][C:11]=3[C:12]=2[CH:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:17][CH:16]=2)O)=[CH:4][CH:3]=1.C>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:32]=[C:31]([OH:33])[CH:30]=[CH:29][C:11]=3[C:12]=2[CH2:13][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH2:22][CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:19][CH:20]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 297MethaneHCID 12968234[2-(4-Hydroxyphenyl)-6-hydroxybenzofuran-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanol

Product 1

HCID 12968235HCID 12968235, compoundYield 52.4%

Procedure

550 mg (1.2 mmol) of the product of Example 11 was reduced to the methane by the method described in Example 2. This yielded 270 mg of the title compound as an amorphous powder.

Sources & evidence

ORD record
ord-a651520f5faa4759b844c557107e3616
Source dataset
uspto-grants-2002_06
Patent number
US06407243B1

Reaction notes

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