2-Chloro-5-chloromethylthiazole → (2-Chloro-thiazol-5-ylmethyl)-methyl-amine

HRID 2187218Notes

Reaction equation

HRID 2187218 reaction equation
[Cl:1][C:2]1[S:3][C:4]([CH2:7]Cl)=[CH:5][N:6]=1.Cl[C:10]1C(CCl)=CC=C(Cl)[N:11]=1>C(Cl)Cl>[Cl:1][C:2]1[S:3][C:4]([CH2:7][NH:11][CH3:10])=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 27631792-Chloro-5-chloromethylthiazoleHCID 6451791Pyridine, 2,6-dichloro-3-(chloromethyl)-

Product 1

HCID 22450372(2-Chloro-thiazol-5-ylmethyl)-methyl-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction procedure of Reference Example 11 was repeated except that crude 2-chloro-5-chloromethylthiazole was used in lieu of 2,6-dichloro-3-pyridylmethyl chloride and that CH2Cl2 was used as the extractant. The procedure gave the title compound as a crude oil. NMR (CDCl3) δ: 2.45 (s, MeN), 3.89 (s, CH2), 7.37 (s, thiazole-H).

Workup

  1. customThe reaction procedure of Reference Example 11

Sources & evidence

ORD record
ord-776cdc7506f94bf781c60dfb7a990fe1
Source dataset
uspto-grants-2002_06
Patent number
US06407248B1

Reaction notes

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