HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-chloromethylthiazole → (2-Chloro-thiazol-5-ylmethyl)-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-chloromethylthiazole | HCID 2763179 | — |
| Reactant | Pyridine, 2,6-dichloro-3-(chloromethyl)- | HCID 6451791 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Chloro-thiazol-5-ylmethyl)-methyl-amine | HCID 22450372 | — |
Reaction Steps
The reaction procedure of Reference Example 11 was repeated except that crude 2-chloro-5-chloromethylthiazole was used in lieu of 2,6-dichloro-3-pyridylmethyl chloride and that CH2Cl2 was used as the extractant. The procedure gave the title compound as a crude oil. NMR (CDCl3) δ: 2.45 (s, MeN), 3.89 (s, CH2), 7.37 (s, thiazole-H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06407248B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-776cdc7506f94bf781c60dfb7a990fe1 |
| Source note | uspto-grants-2002_06 |