Chloro-N,N-dimethylformiminium chloride → HCID 18475305, compound

HRID 2187343Notes

Reaction equation

HRID 2187343 reaction equation
[Cl-].Cl[CH:3]=[N+:4]([CH3:6])[CH3:5].[CH3:7][N:8]([CH3:35])[C:9](=[O:34])[C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:11]=1[S:17]([NH:20][C:21]([NH:23][C:24]1[N:29]=[C:28]([O:30][CH3:31])[CH:27]=[C:26]([O:32][CH3:33])[N:25]=1)=[O:22])(=[O:19])=[O:18]>CN(C=O)C>[CH3:35][N:8]([CH3:7])[C:9](=[O:34])[C:10]1[CH:15]=[CH:14][C:13]([N:16]=[CH:3][N:4]([CH3:6])[CH3:5])=[CH:12][C:11]=1[S:17]([NH:20][C:21]([NH:23][C:24]1[N:29]=[C:28]([O:30][CH3:31])[CH:27]=[C:26]([O:32][CH3:33])[N:25]=1)=[O:22])(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 77311Chloro-N,N-dimethylformiminium chlorideHCID 108627955-amino-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-dimethylaminocarbonylbenzenesulfonamide

Product 1

HCID 18475305HCID 18475305, compoundYield 71.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.24 g of (chloromethylene)dimethylammonium chloride is added to a mixture of 0.80 g of N,N-dimethyl-4-amino-2-[[[[(4,6-dimethoxypyrimidin-2-yl)amino]carbonyl]amino]sulfonyl]benzamide and 8 ml of DMF. Stirring is then continued at room temperature until the reaction has ended. Volatile components are then distilled off under reduced pressure. The residue is washed with water and ethyl acetate. After drying, 0.64 g of the desired product is obtained. Melting point: 140-141° C. (decomp.)

Workup

  1. customis then continued at room temperature until the reaction
  2. distillationVolatile components are then distilled off under reduced pressure
  3. washThe residue is washed with water and ethyl acetate
  4. customAfter drying

Sources & evidence

ORD record
ord-2cd1078274bb47a18ee32f243098c13e
Source dataset
uspto-grants-2002_06
Patent number
US06410482B1

Reaction notes

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