HCID 18475684, compound → 6-Fluoroquinoline-4-carboxylic acid

HRID 2187361Notes

Reaction equation

HRID 2187361 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](C(O)=O)[CH:6]=[C:5]2[C:15]([OH:17])=[O:16]>[N+](C1C=CC=CC=1)([O-])=O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[C:15]([OH:17])=[O:16]

Participants

3

Reactant 1

HCID 18475684HCID 18475684, compound

Product 1

HCID 184755256-Fluoroquinoline-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Procedure

6-Fluoroquinoline-2,4-dicarboxylic acid (14.2 g) in nitrobenzene (50 ml) was boiled for 30 min in a reaction vessel equipped with a Dean-Stark apparatus. The mixture was cooled to room temperature and the precipitated material triturated with 60-80 petroleum ether (500 ml). The solid precipitated title compound (10.50 g) was collected by filtration and dried in vacuao.

Workup

  1. customequipped with a Dean-Stark apparatus
  2. customthe precipitated material triturated with 60-80 petroleum ether (500 ml)
  3. customThe solid precipitated title compound (10.50 g)
  4. filtrationwas collected by filtration
  5. customdried in vacuao

Sources & evidence

ORD record
ord-c71f47bbddc943ec9dedaadcf368124a
Source dataset
uspto-grants-2002_06
Patent number
US06410529B1

Reaction notes

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