HCID 18475684, compound → 6-Fluoroquinoline-4-carboxylic acid

Participants

Reaction Steps

6-Fluoroquinoline-2,4-dicarboxylic acid (14.2 g) in nitrobenzene (50 ml) was boiled for 30 min in a reaction vessel equipped with a Dean-Stark apparatus. The mixture was cooled to room temperature and the precipitated material triturated with 60-80 petroleum ether (500 ml). The solid precipitated title compound (10.50 g) was collected by filtration and dried in vacuao.

Provenance & Evidence