Sodium Hydroxide → HCID 18475415, compound

HRID 2187369Notes

Reaction equation

HRID 2187369 reaction equation
C([O:3][C:4](=[O:31])[CH:5]([C:24]1[CH:25]=[N:26][C:27]([CH3:30])=[N:28][CH:29]=1)[CH2:6][CH2:7][C:8](=[O:23])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[CH2:19][CH2:18][CH2:17][NH:16][C:15]=2[N:14]=1)C.[OH-].[Na+]>C(O)C>[CH3:30][C:27]1[N:28]=[CH:29][C:24]([CH:5]([CH2:6][CH2:7][C:8](=[O:23])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[CH2:19][CH2:18][CH2:17][NH:16][C:15]=3[N:14]=2)[C:4]([OH:31])=[O:3])=[CH:25][N:26]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69393596HCID 69393596, compound

Product 1

HCID 18475415HCID 18475415, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-10a (0.15 g, 0.353 mmol) in ethanol (1 mL) was added NaOH (0.39 rnL of 1N solution in water, 0.39 mmol). After 30 minutes, the mixture was concentrated, and the residue chromatographed on silica gel (20:10:1:1 to 10:10:1:1 ethyl acetate/ethanol/NH4OH/water) to give 1-11a as a white solid.

Workup

  1. concentrationthe mixture was concentrated
  2. customthe residue chromatographed on silica gel (20:10:1:1 to 10:10:1:1 ethyl acetate/ethanol/NH4OH/water)

Sources & evidence

ORD record
ord-c36a6779ef9d414097586960c3d788ca
Source dataset
uspto-grants-2002_06
Patent number
US06410526B1

Reaction notes

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