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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2187374Generated: October 30, 2026

3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)-acrylic acid ethyl ester → Ethyl 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-YL)propanoate

https://huagongshe.com/reaction/2187374

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)-acrylic acid ethyl esterHCID 69370125—
ReactantHCID 178418361HCID 178418361—
CatalystHCID 178418390HCID 178418390—
SolventEthanolHCID 702—
ProductEthyl 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-YL)propanoateHCID 23581268—

Reaction Steps

A mixture of 2-8 (1.4 g, 6.03 mmol) and 10% Pd/carbon (1 g) in EtOH (30 mL) was stirred under a balloon of hydrogen for 18 h. Filtration and evaporative removal of the solvent gave 2-9 as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06410526B1
Source datasetuspto-grants-2002_06
ORD IDord-66e7c52c55c24f1eaa7c3828323b30e0
Source noteuspto-grants-2002_06