Sodium Hydroxide → 3-(2-Methyl-pyrimidin-5-yl)-7-oxo-9-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-nonanoic Acid

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Reaction Steps

To a solution of 2-12 (77 mg, 0.18 mmol) in EtOH (2 mL) was added 1N NaOH (272 μl, 0.27 mmol). After stirring for 2 h, the solvents were evaporated and the residue was chromatographed (silica gel, 25:10:1:1 to 15:10:1:1 EtOAc/EtOH/H2O/NH4OH) to give 2-13 as a white solid.

Provenance & Evidence