Lithium Hydroxide → HCID 18475442, compound

Participants

Reaction Steps

The ester 15-6 (20 mg, 0.05 mmol) in THF (10 mL) and water (10 mL) was treated with 1 N LiOH (1.0 mL, 1.0 mmol). After stirring at room temperature for 1 hour, the solution was concentrated to 5 mL and purified by reverse phase HPLC (preppak C-18 column; water/acetonitrile/0.1% TFA gradient). After lyophilization, the title compound 15-7 (TFA salt) was obtained as a white powder.

Provenance & Evidence