Lithium Hydroxide → HCID 18475442, compound

HRID 2187394Notes

Reaction equation

HRID 2187394 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][CH:6]([C:22]1[CH:23]=[N:24][C:25]([CH3:28])=[N:26][CH:27]=1)[CH2:7][C:8](=[O:21])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[N:18]=[C:17]([NH2:19])[N:16]=[C:15]([NH2:20])[CH:14]=1)C.[Li+].[OH-]>C1COCC1.O>[NH2:19][C:17]1[N:16]=[C:15]([NH2:20])[CH:14]=[C:13]([CH2:12][CH2:11][CH2:10][CH2:9][C:8](=[O:21])[CH2:7][CH:6]([C:22]2[CH:27]=[N:26][C:25]([CH3:28])=[N:24][CH:23]=2)[CH2:5][C:4]([OH:29])=[O:3])[N:18]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 70091948HCID 70091948, compound

Product 1

HCID 18475442HCID 18475442, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The ester 15-6 (20 mg, 0.05 mmol) in THF (10 mL) and water (10 mL) was treated with 1 N LiOH (1.0 mL, 1.0 mmol). After stirring at room temperature for 1 hour, the solution was concentrated to 5 mL and purified by reverse phase HPLC (preppak C-18 column; water/acetonitrile/0.1% TFA gradient). After lyophilization, the title compound 15-7 (TFA salt) was obtained as a white powder.

Workup

  1. concentrationthe solution was concentrated to 5 mL
  2. custompurified by reverse phase HPLC (preppak C-18 column; water/acetonitrile/0.1% TFA gradient)

Sources & evidence

ORD record
ord-751c0ddac9674fecb69bc186aae774cb
Source dataset
uspto-grants-2002_06
Patent number
US06410526B1

Reaction notes

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