5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide → HCID 59191193, compound

HRID 218753Notes

Reaction equation

HRID 218753 reaction equation
[CH2:1]([C:3]1[S:4][C:5]([CH2:12]O)=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1)[CH3:2].[CH2:14]([O:21][C:22]1[CH:31]=[CH:30][CH:29]=[C:28]2[C:23]=1[CH2:24][CH2:25][CH2:26][CH:27]2[C:32]([NH:34][C:35]1[CH:36]=[N:37][C:38]([CH:41]([CH3:43])[CH3:42])=[CH:39][CH:40]=1)=[O:33])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:21][C:22]1[CH:31]=[CH:30][CH:29]=[C:28]2[C:23]=1[CH2:24][CH2:25][CH2:26][CH:27]2[C:32]([N:34]([CH2:12][C:5]1[S:4][C:3]([CH2:1][CH3:2])=[N:7][C:6]=1[C:8]([F:9])([F:10])[F:11])[C:35]1[CH:36]=[N:37][C:38]([CH:41]([CH3:43])[CH3:42])=[CH:39][CH:40]=1)=[O:33])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 178542155-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamideHCID 178544462-Ethyl-4-(trifluoromethyl)-5-thiazolemethanol

Product 1

HCID 59191193HCID 59191193, compoundYield 22.6%

Procedure

By the reaction and treatment in the same manner as in Example 142 using 2-ethyl-5-hydroxymethyl-4-trifluoromethylthiazole (0.63 g) and 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.2 g) as starting materials, 5-benzyloxy-N-[(2-ethyl-4-trifluoromethylthiazol-5-yl)methyl]-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.4 g) was obtained.

Sources & evidence

ORD record
ord-31c8fac5d65d471fb20c2d18c3ae72f2
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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