Benzaldehyde → HCID 53914892, compound

HRID 2187649Notes

Reaction equation

HRID 2187649 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C:10]1[NH:11][CH2:12][CH2:13][N:14]=1>C1(C)C=CC=CC=1>[C:2]1([CH:1]=[CH:9][C:10]2[NH:14][CH2:13][CH2:12][N:11]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 107982-Methylimidazoline

Product 1

HCID 53914892HCID 53914892, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 5.3 g (50 mmol) of benzaldehyde and 4.2 g (50 mmol) of 2-methyl-4,5-dihydro-1H imidazole in 50 ml toluene was refluxed in a Dean-Stark apparatus. Within 8 h 0.9 ml of water had been separated and the reaction was almost complete as detected by TLC. After cooling the crystalline precipitate was filtered off, treated with cold tert.-butylmethylether, and dried in vacuo.

Workup

  1. customWithin 8 h 0.9 ml of water had been separated
  2. temperatureAfter cooling the crystalline precipitate
  3. filtrationwas filtered off
  4. additiontreated with cold tert.-butylmethylether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-f8fdb199a1934ea4b811ce7cb5ac3724
Source dataset
uspto-grants-2002_06
Patent number
US06410562B1

Reaction notes

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