反应详情

温度

100 °C

11.0 g (28.4 mmol) of 3-[2-(t-butoxycarbonylamino)ethoxy]-4iodobenzonitrile was dissolved in 200 ml of DMF. 15.4 ml (142 mmol) of ethyl acrylate, 20 ml (142 mmol) of triethylamine and 127 mg (0.567 mmol) of palladium acetate were added to the obtained solution. They were stirred at 100° C. overnight and then treated with ethyl acetate as the extraction solvent in an ordinary manner to obtain the crude product. After the purification by the silica gel column chromatography, the title compound was obtained.

1. customto obtain the crude product
2. customAfter the purification by the silica gel column chromatography