Hydrochloric Acid → Hydrochloric Acid

HRID 2187933Notes

Reaction equation

HRID 2187933 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][C:10]=1[O:17][CH2:18][CH2:19][NH:20]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28]>O1CCOCC1>[ClH:28].[NH2:20][CH2:19][CH2:18][O:17][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:13]#[N:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 226451464-Benzyloxy-3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile

Product 2

HCID 313Hydrochloric AcidHCID 226451763-(2-Aminoethoxy)-4-benzyloxybenzonitrile

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.4 g (9.2 mmol) of 4-benzyloxy-3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile was dissolved in 40 ml of 4 N solution of hydrogen chloride in dioxane, and the obtained solution was stirred overnight. The solvent was evaporated to obtain hydrochloride of the crude title compound.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-35dbfe6d105a47319274c772424495a8
Source dataset
uspto-grants-2002_06
Patent number
US06410538B2

Reaction notes

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