Hydrochloric Acid → Hydrochloric Acid

HRID 2187959Notes

Reaction equation

HRID 2187959 reaction equation
C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[C:15]#[N:16])=O)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[C:15]#[N:16]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 109890793-(Boc-aminoethyloxy)benzonitrile

Product 2

HCID 313Hydrochloric AcidHCID 22645198210963-99-8

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.41 g of 3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile was dissolved in 20 ml of 4 N solution of hydrogen chloride in dioxane, and the obtained solution was stirred at room temperature for 2 hours. The solvent was evaporated, and the residue was suspended in dichloromethane. The obtained suspension was filtered to obtain hydrochloride of the title compound.

Workup

  1. customThe solvent was evaporated
  2. filtrationThe obtained suspension was filtered

Sources & evidence

ORD record
ord-562b0553431e4271b0dd458002081413
Source dataset
uspto-grants-2002_06
Patent number
US06410538B2

Reaction notes

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