HRID21880

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C(=O)OCC)N(C(C)=O)CC2

HCID178439976

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C(=O)[O-])N(C(C)=O)CC2.CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C(=O)[O-])N(C(C)=O)CC2.[Na+].[Na+]

HCID178439980

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of ethyl 2-n-propyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (50.0 g) in methanol (500 ml) is added 4N aqueous sodium hydroxide solution (50 ml) under ice-cooling. The mixture is stirred overnight at room temperature, then evaporated. The residue is recrystallized from ethanol to give 2-n-propyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylic acid disodium salt (44.3 g).

WORKUP

后处理

temperaturecooling
customevaporated
customThe residue is recrystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e59cdd3c1a5540e9a90a714f0185836e
来源数据集: uspto-grants-1995_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05424316
来源说明: uspto-grants-1995_06

反应 SMILES

[CH2:1]([C:4]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:7]2[CH:8]([C:15]([O:17]CC)=[O:16])[N:9]([C:12](=[O:14])[CH3:13])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3].[OH-].[Na+:40]>CO>[Na+:40].[Na+:40].[CH2:1]([C:4]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:7]2[CH:8]([C:15]([O-:17])=[O:16])[N:9]([C:12](=[O:14])[CH3:13])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3].[CH2:1]([C:4]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:7]2[CH:8]([C:15]([O-:17])=[O:16])[N:9]([C:12](=[O:14])[CH3:13])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3]