Sodium Hydroxide → HCID 178439980, compound

HRID 21880Notes

Reaction equation

HRID 21880 reaction equation
[CH2:1]([C:4]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:7]2[CH:8]([C:15]([O:17]CC)=[O:16])[N:9]([C:12](=[O:14])[CH3:13])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3].[OH-].[Na+:40]>CO>[Na+:40].[Na+:40].[CH2:1]([C:4]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:7]2[CH:8]([C:15]([O-:17])=[O:16])[N:9]([C:12](=[O:14])[CH3:13])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3].[CH2:1]([C:4]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:7]2[CH:8]([C:15]([O-:17])=[O:16])[N:9]([C:12](=[O:14])[CH3:13])[CH2:10][CH2:11][C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178439976HCID 178439976, compound

Product 1

HCID 178439980HCID 178439980, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of ethyl 2-n-propyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (50.0 g) in methanol (500 ml) is added 4N aqueous sodium hydroxide solution (50 ml) under ice-cooling. The mixture is stirred overnight at room temperature, then evaporated. The residue is recrystallized from ethanol to give 2-n-propyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylic acid disodium salt (44.3 g).

Workup

  1. temperaturecooling
  2. customevaporated
  3. customThe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-e59cdd3c1a5540e9a90a714f0185836e
Source dataset
uspto-grants-1995_06
Patent number
US05424316

Reaction notes

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