Sodium Hydroxide → HCID 178439980, compound

Participants

Reaction Steps

To a solution of ethyl 2-n-propyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (50.0 g) in methanol (500 ml) is added 4N aqueous sodium hydroxide solution (50 ml) under ice-cooling. The mixture is stirred overnight at room temperature, then evaporated. The residue is recrystallized from ethanol to give 2-n-propyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylic acid disodium salt (44.3 g).

Provenance & Evidence