HCID 17854370, compound → HCID 59597422, compound

HRID 218809Notes

Reaction equation

HRID 218809 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([NH:21][C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=1)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:30][C:31]1[S:35][C:34]([CH2:36][CH3:37])=[N:33][C:32]=1[CH3:38]>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([N:21]([CH2:30][C:31]1[S:35][C:34]([CH2:36][CH3:37])=[N:33][C:32]=1[CH3:38])[C:22]1[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=1)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 17854370HCID 17854370, compoundHCID 17854442Thiazole, 5-(chloromethyl)-2-ethyl-4-methyl-

Product 1

HCID 59597422HCID 59597422, compoundYield 46.8%

Procedure

By the reaction and treatment in the same manner as in Example 132 using 5-benzyloxy-N-(5-methylpyridin-2-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.43 g) and 5-chloromethyl-2-ethyl-4-methylthiazole (0.68 g) as starting materials, 5-benzyloxy-N-[(2-ethyl-4-methylthiazol-5-yl)methyl]-N-(5-methylpyridin-2-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.92 g) was obtained.

Sources & evidence

ORD record
ord-8dd0f3d0f59543ce870291558af76773
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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