Hydrochloric Acid → HCID 70167927, compound

HRID 2188203Notes

Reaction equation

HRID 2188203 reaction equation
C([CH2:8][NH:9][CH2:10][C:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[C:12]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)C1C=CC=CC=1.[ClH:28]>C(O)C.[Pd]>[ClH:28].[F:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[C@@H:12]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C@@H:11]([CH2:10][NH:9][CH3:8])[CH2:20][CH2:19]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18477085HCID 18477085, compound

Product 1

HCID 70167927HCID 70167927, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixture of 2-(N-benzylmethylamino)methyl-6-fluoro-1-phenyl-3,4-dihydronaphthalene (0.95 g) in ethyl alcohol (50 cm3) and hydrochloric acid (5 M, 1 cm3) was added palladium on charcoal (5%, 0.25 g). The resultant mixture was stirred under an atmosphere of hydrogen at a pressure of 2 atm at room temperature for 60 h. The catalyst was removed by filtration through a pad of Dicalite® and the solvent was evaporated under reduced pressure to provide the title compound (0.75 g) as a white solid.

Workup

  1. customThe catalyst was removed by filtration through a pad of Dicalite®
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-76a0d8a0d52548969fe6864a4c4b764f
Source dataset
uspto-grants-2002_06
Patent number
US06410592B1

Reaction notes

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