Hydrochloric Acid → HCID 75421021, compound

HRID 2188222Notes

Reaction equation

HRID 2188222 reaction equation
C([O:3][C:4](=[O:23])[C:5]([NH:19]C(=O)C)([CH2:11][C:12]#[C:13][CH2:14][NH:15]C(=O)C)C(OCC)=O)C.[ClH:24]>C(O)(=O)C>[ClH:24].[ClH:24].[NH2:19][CH:5]([CH2:11][C:12]#[C:13][CH2:14][NH2:15])[C:4]([OH:23])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53712490HCID 53712490, compound

Product 1

HCID 75421021HCID 75421021, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Acetamido(4-acetamido-2-butynyl)-malonic acid diethyl ester (7.64 g) was dissolved in a mixture of acetic acid (140 ml) and a 6M hydrochloric acid solution (290 ml), and heated overnight at 95° C. The mixture was concentrated in vacuo. The residue was crystallized from ethanol/water yielding 2,6-diamino-4-hexynoic acid dihydrochloride as a crystalline powder (4.0 g).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was crystallized from ethanol/water

Sources & evidence

ORD record
ord-bd4c4340974d4dd29ecb66f702343ffc
Source dataset
uspto-grants-2002_06
Patent number
US06410684B1

Reaction notes

Loading…