Cyclo(-Gly-Phe) → (S)-2-Benzylpiperazine

HRID 2188473Notes

Reaction equation

HRID 2188473 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C@H:14]1[C:19](=O)[NH:18][CH2:17][C:16](=O)[NH:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCCC1>[CH2:7]([C@H:14]1[CH2:19][NH:18][CH2:17][CH2:16][NH:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 7076549Cyclo(-Gly-Phe)HCID 21226445Aluminium lithium hydride

Product 1

HCID 20760001(S)-2-Benzylpiperazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

At ice-bath temperature, lithium aluminium hydride (1.6 g, 42.16 mmol) was added in portions to a stirring mixture of (S)-2-benzylpiperazine-3,6-dione; (3.0 g, 14.70 mmol) and tetrahydrofuran (80 ml). After 30 min at ice-bath temperature, the mixture was refluxed for 4 h with stirring. The reaction was quenched by the portionwise addition of sodium sulfate decahydrate and some methanol until hydrogen evolution ceased. It was filtered and the solids were washed several times with dichloromethane. The combined filtrates were evaporated to leave a white solid. MS (m/z): 177.1 (M+H)+; C11H16N2 requir. 176.3.

Workup

  1. temperaturethe mixture was refluxed for 4 h
  2. customThe reaction was quenched by the portionwise addition of sodium sulfate decahydrate
  3. filtrationIt was filtered
  4. washthe solids were washed several times with dichloromethane
  5. customThe combined filtrates were evaporated
  6. customto leave a white solid

Sources & evidence

ORD record
ord-017ba39f56e8497bae7e903e7c2013e6
Source dataset
uspto-grants-2002_06
Patent number
US06410729B1

Reaction notes

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