4-(4-methylpiperazin-1-yl)benzoyl Chloride → HCID 87201939, compound

HRID 2188738Notes

Reaction equation

HRID 2188738 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:17][O:18][C:19]1[CH:63]=[C:62]([O:64][CH3:65])[CH:61]=[C:60]([O:66][CH3:67])[C:20]=1[CH:21]=[CH:22][CH:23]([S:33]([CH:36]([CH:46]=[CH:47][C:48]1[C:53]([O:54][CH3:55])=[CH:52][C:51]([O:56][CH3:57])=[CH:50][C:49]=1[O:58][CH3:59])[C:37]1[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[C:39]([NH2:45])[CH:38]=1)(=[O:35])=[O:34])[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([NH2:32])[CH:25]=1>O1CCCC1>[CH3:67][O:66][C:60]1[CH:61]=[C:62]([O:64][CH3:65])[CH:63]=[C:19]([O:18][CH3:17])[C:20]=1/[CH:21]=[CH:22]/[CH:23]([S:33]([CH:36](/[CH:46]=[CH:47]/[C:48]1[C:49]([O:58][CH3:59])=[CH:50][C:51]([O:56][CH3:57])=[CH:52][C:53]=1[O:54][CH3:55])[C:37]1[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[C:39]([NH:45][C:12](=[O:13])[C:11]2[CH:10]=[CH:9][C:8]([N:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]3)=[CH:16][CH:15]=2)[CH:38]=1)(=[O:35])=[O:34])[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([NH:32][C:12](=[O:13])[C:11]2[CH:15]=[CH:16][C:8]([N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[CH:9][CH:10]=2)[CH:25]=1

Participants

4

Reactant 2

HCID 116300684-(4-methylpiperazin-1-yl)benzoyl ChlorideHCID 66912535HCID 66912535, compound

Product 1

HCID 87201939HCID 87201939, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 4-(4-methylpiperazin-1-yl)benzoyl chloride (10 mmol) in tetrahydrofuran (40 mL) is added dropwise a solution of 2,4,6-trimethoxystyryl-3-amino-4-methoxybenzylsulfone (10 mmol) in tetrahydrofuran. The solution is stirred overnight and the reaction progress is monitored by TLC. The solvent is removed and the residue is taken up in dichloromethane and washed with water. The organic layer is dried over anhydrous sodium sulfate and evaporated to give the desired amide product.

Workup

  1. customThe solvent is removed
  2. washwashed with water
  3. dry with materialThe organic layer is dried over anhydrous sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-be78b0a3fc804af5ac903286a0b0d1b8
Source dataset
uspto-grants-2012_12
Patent number
US08324190B2

Reaction notes

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