HRID2189005

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O

HCID2724762

tert-Butoxycarbonyl-L-isoleucine

C11H21NO4

结构：CC(O)C(O)C1CNc2[nH]c(N=CN(C)C)nc(=O)c2N1C(=O)OC(C)(C)C

HCID178469704

未命名化合物

PRODUCTS

生成物

结构：CCC(C)C(NC(=O)OC(C)(C)C)C(=O)OC(C)C(O)C1CNc2[nH]c(N=CN(C)C)nc(=O)c2N1C(=O)OC(C)(C)C

HCID178446792

未命名化合物

收率 40%

PROCEDURE

实验过程

The product of Example 5, step b) was treated by the same method as that described in Example 5, step c) except N-Boc-L-Isoleucine (3.70 g, 16 mmol) was used to give the sub-title compound as a light yellow solid (0.29 g, 40%). The product obtained after chromatography still contained impurities and was used for the next step without further purification. MS: ESI (positive): 610 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-440b49a16a6a46c1b15597181e74cb12
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08324210B2
来源说明: uspto-grants-2012_12

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH:17]([CH:18]([OH:22])[CH:19]([OH:21])[CH3:20])[CH2:16][NH:15][C:14]2[NH:13][C:12]([N:23]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:11][C:10](=[O:28])[C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:29]([NH:36][C@H:37]([C:42](O)=[O:43])[C@H:38]([CH2:40][CH3:41])[CH3:39])([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[C:1]([O:5][C:6]([N:8]1[CH:17]([CH:18]([OH:22])[CH:19]([O:21][C:42](=[O:43])[CH:37]([NH:36][C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH:38]([CH3:39])[CH2:40][CH3:41])[CH3:20])[CH2:16][NH:15][C:14]2[NH:13][C:12]([N:23]=[CH:24][N:25]([CH3:26])[CH3:27])=[N:11][C:10](=[O:28])[C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2]