1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → Pyrrolidine-1,2-dicarboxylic acid

HRID 2189008Notes

Reaction equation

HRID 2189008 reaction equation
C(OC(N1C(C(O)C(O)C)CNC2NC(N=CN(C)C)=NC(=O)C1=2)=O)(C)(C)C.[C:29]([N:36]1[CH2:43][CH2:42][CH2:41][C@H:37]1[C:38]([OH:40])=[O:39])([O:31]C(C)(C)C)=[O:30]>>[N:36]1([C:29]([OH:31])=[O:30])[CH2:43][CH2:42][CH2:41][CH:37]1[C:38]([OH:40])=[O:39]

Participants

3

Reactant 2

HCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 178469704HCID 178469704, compound

Product 1

HCID 14794868Pyrrolidine-1,2-dicarboxylic acidYield 321.1%

Procedure

The product of Example 5, step b) was treated by the same method as that described in Example 10, step a) except N-Boc-L-Proline (12.6 g, 5.87 mmol) was used to give the sub-title compound as a pale yellow solid (3.0 g, 60%). MS: ESI (positive): 791 (M+H).

Sources & evidence

ORD record
ord-c8ba5ea9e3204ee78dc2a52a6b18696e
Source dataset
uspto-grants-2012_12
Patent number
US08324210B2

Reaction notes

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