反应详情

温度

50 °C

Initially charge 50 g (359.4 mmol) of 3-nitrophenol and 175.67 g (539 mmol) of caesium carbonate in 1.0 liter of acetone and add 71.5 g (467.3 mmol) of bromoacetic acid methyl ester. Stir the mixture at 50° C. for 1 h and, after cooling, pour onto 7.5 liters of water. Stir the suspension for 30 min, then filter off with suction and wash the filter residue with water. Dry the solid in a drying cabinet at 50° C. and 100 mbar. 64.3 g (84.7% of theory) of the target compound are obtained.

1. temperatureafter cooling
2. stirringStir the suspension for 30 min
3. filtrationfilter off with suction
4. washwash the filter residue with water
5. customDry the solid in a drying cabinet at 50° C.
6. custom64.3 g (84.7% of theory) of the target compound are obtained