3-Nitrophenoxyacetic acid methyl ester → Methyl 2-(3-aminophenoxy)acetate

Participants

Reaction Steps

Add 1.3 g of palladium on activated carbon (10%) to 13 g (61.6 mmol) of 3-nitrophenoxyacetic acid methyl ester in 150 ml of methanol under argon. Stir the mixture at RT under a hydrogen atmosphere (standard pressure) for 18 h. Filter the catalyst off through kieselguhr and concentrate the filtrate under reduced pressure. After drying under high vacuum, 10.7 g (95.9% of theory) of the target compound are obtained.

Provenance & Evidence