反应详情

Add 570 ml of phosphorus oxychloride to 57 g (200 mmol) of 5,6-diphenylfuro[2,3-d]pyrimidin-4(3H)-one. Stir the mixture under reflux for 3 h, then cool it and concentrate it under reduced pressure. Stir the residue with ice-water for 30 min and then admix it with dichloromethane. Wash the resulting organic phase three times with water, dry it over sodium sulphate and concentrate it under reduced pressure. 58 g (93.2% of theory) of the target product are obtained.

1. temperatureunder reflux for 3 h
2. temperaturecool it
3. concentrationconcentrate it under reduced pressure
4. stirringStir the residue with ice-water for 30 min
5. washWash the resulting organic phase three times with water
6. dry with materialdry it over sodium sulphate
7. concentrationconcentrate it under reduced pressure
8. custom58 g (93.2% of theory) of the target product are obtained