反应详情

温度

50 °C

Dissolve 107 mg (0.209 mmol) of 3-{[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-phenoxyacetic acid methyl ester in 2 ml of THF, add 0.628 ml of 1N sodium hydroxide solution at RT and stir at 50° C. for 1 h. Cool to RT and remove the THF under reduced pressure. Add water to the residue and then, with ice cooling, 1N hydrochloric acid. Filter off the precipitated solid, wash repeatedly with water and dry at 40° C. under reduced pressure. 92.5 mg (88.9% of theory) of the target compound are obtained as white solid.

1. temperatureCool to RT
2. customremove the THF under reduced pressure
3. filtrationFilter off the precipitated solid
4. washwash repeatedly with water
5. customdry at 40° C. under reduced pressure
6. custom92.5 mg (88.9% of theory) of the target compound are obtained as white solid