Hydrochloric Acid → HCID 25095386, compound

Participants

Reaction Conditions

Reaction Steps

Initially charge 137 mg (0.285 mmol) of 3-(4-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]-pyrimidin-4-yl]oxy}phenyl)propanoic acid methyl ester in 4.5 ml of THF, and add 0.855 ml of 1N sodium hydroxide solution at RT. Stir the mixture at 50° C. for 1 h. After cooling, acidify with 1N hydrochloric acid and filter off the precipitated solid with suction, wash with water and dry under high vacuum. 125.9 mg (94.7% of theory) of the target compound are obtained.

Provenance & Evidence