Hydrochloric Acid → HCID 25095386, compound

HRID 2189102Notes

Reaction equation

HRID 2189102 reaction equation
C[O:2][C:3](=[O:36])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[C:14]3[C:21]([C:22]4[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=4)=[C:20]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[O:19][C:15]=3[N:16]=[CH:17][N:18]=2)=[CH:8][CH:7]=1.[OH-].[Na+].Cl>C1COCC1>[CH3:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([C:21]2[C:14]3[C:13]([O:12][C:9]4[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][C:3]([OH:36])=[O:2])=[CH:7][CH:8]=4)=[N:18][CH:17]=[N:16][C:15]=3[O:19][C:20]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 25095385HCID 25095385, compound

Product 1

HCID 25095386HCID 25095386, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

Initially charge 137 mg (0.285 mmol) of 3-(4-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]-pyrimidin-4-yl]oxy}phenyl)propanoic acid methyl ester in 4.5 ml of THF, and add 0.855 ml of 1N sodium hydroxide solution at RT. Stir the mixture at 50° C. for 1 h. After cooling, acidify with 1N hydrochloric acid and filter off the precipitated solid with suction, wash with water and dry under high vacuum. 125.9 mg (94.7% of theory) of the target compound are obtained.

Workup

  1. temperatureAfter cooling
  2. filtrationfilter off the precipitated solid with suction
  3. washwash with water
  4. customdry under high vacuum
  5. custom125.9 mg (94.7% of theory) of the target compound are obtained

Sources & evidence

ORD record
ord-acd466d9634342de80e344a3d65989ee
Source dataset
uspto-grants-2012_12
Patent number
US08324222B2

Reaction notes

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