反应详情

Heat 300 mg (0.89 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 191.3 mg (1.16 mmol) of 3-aminophenylacetic acid methyl ester to 150° C. for 1.5 h. After cooling, add dichloromethane and filter off the resulting solid with suction, wash with dichloromethane and dry at 50° C. under high vacuum overnight. Purify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 10:1). 273.2 mg (65.9% of theory) of the target product are obtained as a yellowish solid.

1. temperatureAfter cooling
2. filtrationfilter off the resulting solid with suction
3. washwash with dichloromethane
4. customdry at 50° C. under high vacuum overnight
5. customPurify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 10:1)
6. custom273.2 mg (65.9% of theory) of the target product are obtained as a yellowish solid