Methyl 3-aminophenylacetate → 3-{[5-(4-Methoxy-phenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester

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Reaction Steps

Heat 300 mg (0.89 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 191.3 mg (1.16 mmol) of 3-aminophenylacetic acid methyl ester to 150° C. for 1.5 h. After cooling, add dichloromethane and filter off the resulting solid with suction, wash with dichloromethane and dry at 50° C. under high vacuum overnight. Purify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 10:1). 273.2 mg (65.9% of theory) of the target product are obtained as a yellowish solid.

Provenance & Evidence