Sodium Hydroxide → 3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid

Participants

Reaction Conditions

Reaction Steps

Dissolve 50 mg (0.107 mmol) of 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester in 2 ml of THF, add 0.322 ml of 1N sodium hydroxide solution at RT and stir at 50° C. for 4 h. Cool to RT and remove the THF under reduced pressure. Add water to the residue, and then 1N hydrochloric acid. Filter off the precipitated solid, wash with water and dry at 50° C. under reduced pressure. 41.7 mg (86% of theory) of the target compound are obtained as a white solid.

Provenance & Evidence