反应详情

温度

50 °C

Dissolve 50 mg (0.107 mmol) of 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenylacetic acid methyl ester in 2 ml of THF, add 0.322 ml of 1N sodium hydroxide solution at RT and stir at 50° C. for 4 h. Cool to RT and remove the THF under reduced pressure. Add water to the residue, and then 1N hydrochloric acid. Filter off the precipitated solid, wash with water and dry at 50° C. under reduced pressure. 41.7 mg (86% of theory) of the target compound are obtained as a white solid.

1. temperatureCool to RT
2. customremove the THF under reduced pressure
3. filtrationFilter off the precipitated solid
4. washwash with water
5. customdry at 50° C. under reduced pressure
6. custom41.7 mg (86% of theory) of the target compound are obtained as a white solid