反应详情

Heat 0.85 mg (0.183 mmol) of 2-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)acetic hydrazide and 35.5 mg (0.219 mmol) of N,N′-carbonyldiimidazole under reflux in 3 ml of THF for 2 h. After cooling to RT, add to water and extract repeatedly with dichloromethane. Dry the combined organic phases over magnesium sulphate and concentrate under reduced pressure. 79.9 mg (89% of theory) of the target product are obtained as a beige solid.

1. extractionextract repeatedly with dichloromethane
2. dry with materialDry the combined organic phases over magnesium sulphate
3. concentrationconcentrate under reduced pressure
4. custom79.9 mg (89% of theory) of the target product are obtained as a beige solid