反应详情

Dissolve 237 mg (0.45 mmol) of {[1-({[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}methyl)cyclobutyl]methoxy}acetic acid tert-butyl ester in 1 ml of dioxane, add 2 ml of 4 N hydrogen chloride in dioxane and stir at RT for 16 h. After concentrating the reaction solution under reduced pressure, purify the residue by means of preparative RP-HPLC (gradient: water/acetonitrile). 180 mg (85% of theory) of the desired product are obtained.

1. concentrationAfter concentrating the reaction solution under reduced pressure
2. custompurify the residue by means of preparative RP-HPLC (gradient: water/acetonitrile)