反应详情

A solution of 2-(2-methoxy-phenyl)-quinazolin-4-ol (2.94 g, 11.65 mmol) in phosphorus oxychloride (60 mL) was heated to reflux for 4.5 hours. The orange reaction mixture was concentrated and the resulting gum was treated with ice-cold saturated sodium bicarbonate (200 mL) and extracted with ethyl acetate (2×200 mL). The organic layers were combined, dried (MgSO4) and concentrated to give the title compound as a yellow solid (2.92 g, 93%).

1. temperatureto reflux for 4.5 hours
2. concentrationThe orange reaction mixture was concentrated
3. additionthe resulting gum was treated with ice-cold saturated sodium bicarbonate (200 mL)
4. extractionextracted with ethyl acetate (2×200 mL)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated