2-Aminobenzonitrile → HCID 136068494, compound

HRID 2189196Notes

Reaction equation

HRID 2189196 reaction equation
C[O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=O.[C:12](#[N:20])[C:13]1[C:14](=[CH:16][CH:17]=[CH:18][CH:19]=1)[NH2:15].[C:21]([O:25][C:26]([N:28]1[CH2:33][CH2:32][CH2:31][C@@H:30]([NH2:34])[CH2:29]1)=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26]([N:28]1[CH2:33][CH2:32][CH2:31][C@@H:30]([NH:34][C:12]2[C:13]3[C:14](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:15]=[C:5]([C:4]3[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=3[OH:2])[N:20]=2)[CH2:29]1)=[O:27])([CH3:24])([CH3:22])[CH3:23]

Participants

4

Reactant 3

HCID 729132-AminobenzonitrileHCID 889692-Methoxybenzoyl chlorideHCID 1501974tert-butyl (3R)-3-aminopiperidine-1-carboxylate

Product 1

HCID 136068494HCID 136068494, compound

Procedure

The title compound was prepared from 2-methoxybenzoyl chloride, anthranilonitrile, and (R)-3-amino-piperidine-1-carboxylic acid tert-butyl ester using methods analogous to those described in Synthesis 1, steps 1A, 1B, and 1D.

Sources & evidence

ORD record
ord-a496ca0bf29643db98593b77dc109f5c
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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