HCID 136068452, compound → HCID 135921476, compound

HRID 2189226Notes

Reaction equation

HRID 2189226 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:20][C@H:21]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]3)=[N:7][C:8]([C:12]3[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=3[OH:19])=[N:9]2)=[CH:4][CH:3]=1.[OH:33][C:34]1C=CC=[CH:36][C:35]=1C1N=C(N[C@H]2CCN(C(OC(C)(C)C)=O)C2)C2C(=CC=C(C#CCO)C=2)N=1>>[F:18][C:16]1[CH:15]=[CH:14][C:13]([OH:19])=[C:12]([C:8]2[N:7]=[C:6]([NH:20][C@H:21]3[CH2:25][CH2:24][NH:23][CH2:22]3)[C:5]3[C:10](=[CH:11][C:2]([CH2:36][CH2:35][CH2:34][OH:33])=[CH:3][CH:4]=3)[N:9]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 136068452HCID 136068452, compoundHCID 136398357HCID 136398357, compound

Product 1

HCID 135921476HCID 135921476, compound

Procedure

The title compound was prepared using methods analogous to those described in Synthesis 59 and 60, replacing (S)-tert-butyl 3-(6-bromo-2-(2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate with (S)-tert-butyl 3-(7-bromo-2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate in Synthesis 59-A.

Workup

  1. customthose described in Synthesis 59 and 60

Sources & evidence

ORD record
ord-0a376c596f5a4a809804bca170bb8181
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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