HCID 135921487, compound → HCID 135921488, compound

HRID 2189231Notes

Reaction equation

HRID 2189231 reaction equation
OC1C=CC=CC=1C1N=C(N[C@H]2CCN(C(OC(C)(C)C)=O)C2)C2C(=CC=C(C#CCO)C=2)N=1.[CH3:35][O:36][CH2:37]/[CH:38]=[CH:39]/[C:40]1[CH:49]=[C:48]2[C:43]([C:44]([NH:57][C@H:58]3[CH2:62][CH2:61][NH:60][CH2:59]3)=[N:45][C:46]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=3[OH:56])=[N:47]2)=[CH:42][CH:41]=1>>[CH3:35][O:36][CH2:37][CH2:38][CH2:39][C:40]1[CH:49]=[C:48]2[C:43]([C:44]([NH:57][C@H:58]3[CH2:62][CH2:61][NH:60][CH2:59]3)=[N:45][C:46]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][C:51]=3[OH:56])=[N:47]2)=[CH:42][CH:41]=1

Participants

3

Reactant 2

HCID 135921487HCID 135921487, compoundHCID 136068452HCID 136068452, compound

Product 1

HCID 135921488HCID 135921488, compound

Procedure

The title compound was synthesised using methods analogous to those described in Synthesis 60 and 85-A, with (S)-tert-butyl 3-(2-(2-hydroxyphenyl)-6-(3-hydroxyprop-1-ynyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate replaced with (S,E)-2-(7-(3-methoxyprop-1-enyl)-4-(pyrrolidin-3-ylamino)quinazolin-2-yl)phenol in Synthesis 60.

Sources & evidence

ORD record
ord-a762ccd69f854db09bd0fcaa84a7f9b5
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

Loading…