反应详情

温度

100 °C

To a solution of [2-Chloro-5-((Z)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(1-ethylpropyl)-amine (1.1 g, 4.07 mmol) in EtOH (8 mL) is added concentrated HCl (0.1 mL) at ambient temperature. The reaction mixture is sealed in a microwave reactor and heated at 100° C. for 10 mins. After cooling down the mixture is concentrated in vacuo to provide 2-Chloro-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine. The crude product is used as it is. The material can be purified by flash chromatography (SiO2, EtOAc:Hexane=1:5).

1. customThe reaction mixture is sealed in a microwave reactor
2. temperatureAfter cooling down the mixture
3. concentrationis concentrated in vacuo