反应详情

温度

68 °C

To a solution of [2-Chloro-5-(3,3-diethoxy-prop-1-ynyl)-pyrimidin-4-yl]-(1-ethyl-propyl)-amine (326 mg, 1 mmol) in THF (2 mL) is added a solution of 1M TBAF in THF (5 mL, 5 mmol) at ambient temperature. The reaction mixture is heated at 68° C. for 2 hours. After cooling down, the mixture is concentrated in vacuo. The crude product is purified by column chromatography (SiO2, EtOAc:Heptane=5:95 to 40:60) to give 307 mg of the title compound as a colorless oil.

1. temperatureAfter cooling down
2. concentrationthe mixture is concentrated in vacuo
3. customThe crude product is purified by column chromatography (SiO2, EtOAc:Heptane=5:95 to 40:60)