Cyclopentylamine → 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine

HRID 2189301Notes

Reaction equation

HRID 2189301 reaction equation
C1(N)CCCC1.BrC1C(Cl)=NC(Cl)=NC=1.[Cl:16][C:17]1[N:18]=[CH:19][C:20]2[CH:25]=[CH:24][N:23]([CH:26]([CH2:29][CH3:30])[CH2:27][CH3:28])[C:21]=2[N:22]=1>>[Cl:16][C:17]1[N:18]=[CH:19][C:20]2[CH:25]=[CH:24][N:23]([CH:26]3[CH2:29][CH2:30][CH2:28][CH2:27]3)[C:21]=2[N:22]=1

Participants

4

Reactant 3

HCID 2906CyclopentylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 580159322-Chloro-7-(pentan-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 866373422-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine

Procedure

2-chloro-7-(cyclopentyl)-7H-pyrrolo[2,3-d]pyrimidine is prepared from cyclopentyl amine and 5-bromo-2,4-dichloropyrimidine using a method similar to that for the preparation of 2-chloro-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine given in example 1.

Sources & evidence

ORD record
ord-c81192b723b749dda9fac699d766b369
Source dataset
uspto-grants-2012_12
Patent number
US08324225B2

Reaction notes

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