tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate → 1-[7-cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-ethanone

HRID 2189303Notes

Reaction equation

HRID 2189303 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11](=[O:13])[CH3:12])=[CH:9][N:8]([CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)[C:6]=2[N:7]=1.C(OC([N:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:37]=[CH:36][C:35]([NH2:38])=[CH:34][CH:33]=2)[CH2:28][CH2:27]1)=O)(C)(C)C>>[CH:14]1([N:8]2[C:6]3[N:7]=[C:2]([NH:38][C:35]4[CH:34]=[CH:33][C:32]([N:29]5[CH2:30][CH2:31][NH:26][CH2:27][CH2:28]5)=[CH:37][CH:36]=4)[N:3]=[CH:4][C:5]=3[C:10]([C:11](=[O:13])[CH3:12])=[CH:9]2)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 11011301tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylateHCID 866373431-(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethanone

Product 1

HCID 580158451-[7-cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-ethanone

Procedure

1-[7-cyclopentyl-2-(4-piperazin-1-yl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-ethanone is prepared from 1-(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethanone and 4-(4-Aminophenyl)-piperazine-1-carboxylic acid tert-butyl ester using a method similar to that for the preparation of Example 202. [M+H+] 405.2.

Workup

  1. customfor the preparation of Example 202

Sources & evidence

ORD record
ord-e5dbfcec8fa7409ebd550fd7025c3c02
Source dataset
uspto-grants-2012_12
Patent number
US08324225B2

Reaction notes

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