tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate → (7-Cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

HRID 2189305Notes

Reaction equation

HRID 2189305 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]([CH3:13])[CH3:12])=[CH:9][N:8]([CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)[C:6]=2[N:7]=1.C(OC([N:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:33]=[N:34][C:35]([NH2:38])=[CH:36][CH:37]=2)[CH2:28][CH2:27]1)=O)(C)(C)C>>[CH:14]1([N:8]2[C:6]3[N:7]=[C:2]([NH:38][C:35]4[CH:36]=[CH:37][C:32]([N:29]5[CH2:28][CH2:27][NH:26][CH2:31][CH2:30]5)=[CH:33][N:34]=4)[N:3]=[CH:4][C:5]=3[C:10]([CH:11]([CH3:13])[CH3:12])=[CH:9]2)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 11737525tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylateHCID 848198052-Chloro-7-cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 58015852(7-Cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine

Procedure

(7-Cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)-amine is prepared from 2-Chloro-7-cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidine and 4-(6-Amino-pyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester using a method similar to that for the preparation of Example 202. [MH+] 406.21

Workup

  1. customfor the preparation of Example 202

Sources & evidence

ORD record
ord-a26a4a0e130946bfa2df9738bacb9039
Source dataset
uspto-grants-2012_12
Patent number
US08324225B2

Reaction notes

Loading…