反应详情

温度

70 °C

To a solution of [2-chloro-5-(3,3-diethoxy-prop-1-ynyl)-pyrimidin-4-yl]-(1-ethyl-propyl)-amine (326 mg, 1 mmol) in THF (2 mL) is added IN TBAF in THF (5 mL, 5 mmol) at ambient temperature. The reaction mixture is heated at 70° C. for 2 h. After cooling down, the mixture is concentrated in vacuo and purified by BIOTAGE column (EtOAc/heptane 5:5 to 40:60) to give 307 mg of 2-chloro-6-diethoxymethyl-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine as a light yellow oil.

1. temperatureAfter cooling down
2. concentrationthe mixture is concentrated in vacuo
3. custompurified by BIOTAGE column (EtOAc/heptane 5:5 to 40:60)