反应详情

To a solution of 4-[2-chloro-4-(1-ethyl-propylamino)-pyrimidin-5-yl]-but-3-yn-2-ol (0.23 g, 0.85 mmol) in THF (0.5 mL) is added 1M TBAF (4.3 mL). The reaction mixture is heated at reflux for 16 h, diluted with water, extracted with EtOAc. The extracts are dried over Na2SO4 and concentrated in vacuo. The residue is purified by flash chromatography (SiO2, EtOAc/Hexane 1:3) to provide 0.12 g of 1-[2-chloro-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-ethanol.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 16 h
3. extractionextracted with EtOAc
4. dry with materialThe extracts are dried over Na2SO4
5. concentrationconcentrated in vacuo
6. customThe residue is purified by flash chromatography (SiO2, EtOAc/Hexane 1:3)