Cyclopentylamine → 5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine

HRID 2189329Notes

Reaction equation

HRID 2189329 reaction equation
C1(N)CCCC1.BrC1C(Cl)=NC(Cl)=NC=1.[Br:16][C:17]1[C:18]([NH:24][CH:25]([CH2:28][CH3:29])[CH2:26][CH3:27])=[N:19][C:20]([Cl:23])=[N:21][CH:22]=1>>[Br:16][C:17]1[C:18]([NH:24][CH:25]2[CH2:28][CH2:29][CH2:27][CH2:26]2)=[N:19][C:20]([Cl:23])=[N:21][CH:22]=1

Participants

4

Reactant 3

HCID 2906CyclopentylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 580158915-bromo-2-chloro-N-(pentan-3-yl)pyrimidin-4-amine

Product 1

HCID 442482475-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine

Procedure

(5-Bromo-2-chloro-pyrimidin-4-yl)cyclopentylamine is prepared from cyclopentyl amine and 5-bromo-2,4-dichloropyrimidine using a method similar to that for the preparation of (5-Bromo-2-chloro-pyrimidin-4-yl)-(1-ethylpropyl)amine given in Example 137.

Sources & evidence

ORD record
ord-585c64f580d9411295bc87de064372d0
Source dataset
uspto-grants-2012_12
Patent number
US08324225B2

Reaction notes

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